› 9arh

Electron Microscopy
3.69Å resolution

Rat GluN1-GluN2B NMDA receptor channel in complex with glycine

Released:
DOI: 10.2210/pdb9arh/pdb
PDB entry 9arh coloured by chain, front view.
PDB entry 9arh coloured by chain, side view.
PDB entry 9arh coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Molecular mechanism of ligand gating and opening of NMDA receptor
Chou TH, Epstein M, Fritzemeier RG, Akins NS, Paladugu S, Ullman EZ, Liotta DC, Traynelis SF, Furukawa H
Nature (2024)
Related structures: EMD-43782

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152911 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Glutamate receptor ionotropic, NMDA 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 959 amino acids
Theoretical weight: 108.09 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P35439 (Residues: 1-190, 191-938; Coverage: 100%)
  • Best match: P35439-2 (Residues: 1-959)
Gene names: Grin1, Nmdar1
Sequence domains:
Glutamate receptor ionotropic, NMDA 2B Chains: B, D
Molecule details ›
Chains: B, D
Length: 883 amino acids
Theoretical weight: 98.85 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q00960 (Residues: 27-852; Coverage: 57%)
Gene name: Grin2b
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand GLY 2 x GLY
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.69Å
Relevant EMDB volumes: EMD-43782
Expression system: Spodoptera frugiperda

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