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Solution NMR

Function and Biology Details

Reaction catalysed: 
S-adenosyl-L-methionine + a [histone H3]-L-lysine(4) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(4)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-246004 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Histone-lysine N-methyltransferase 2D Chain: A
Molecule details ›
Chain: A
Length: 100 amino acids
Theoretical weight: 11.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14686 (Residues: 227-322; Coverage: 2%)
Gene names: ALR, KMT2D, MLL2, MLL4
Sequence domains: PHD-finger
Putative Polycomb group protein ASXL2 Chain: B
Molecule details ›
Chain: B
Length: 19 amino acids
Theoretical weight: 1.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q76L83 (Residues: 652-670; Coverage: 1%)
Gene names: ASXH2, ASXL2, KIAA1685

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 73%
Refinement method: molecular dynamics
Expression system: Escherichia coli

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