› 9avv

Electron Microscopy
2.09Å resolution

Bovine adult muscle nAChR resting state

Released:
DOI: 10.2210/pdb9avv/pdb
PDB entry 9avv coloured by chain, front view.
PDB entry 9avv coloured by chain, side view.
PDB entry 9avv coloured by chain, top view.
Source organisms:
Primary publication:
Structural switch in acetylcholine receptors in developing muscle.
Li H, Teng J, Hibbs RE
Nature (2024)
PMID: 39085615
Related structures: EMD-43924

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero heptamer (preferred)
PDBe Complex ID:
PDB-CPX-272162 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (9 distinct):
Acetylcholine receptor subunit alpha Chains: A, C
Molecule details ›
Chains: A, C
Length: 437 amino acids
Theoretical weight: 49.95 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P02709 (Residues: 21-457; Coverage: 100%)
Gene name: CHRNA1
Sequence domains:
Acetylcholine receptor subunit beta Chain: E
Molecule details ›
Chain: E
Length: 481 amino acids
Theoretical weight: 55.11 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P04758 (Residues: 25-505; Coverage: 100%)
Gene name: CHRNB1
Sequence domains:
Acetylcholine receptor subunit delta Chain: D
Molecule details ›
Chain: D
Length: 495 amino acids
Theoretical weight: 56.54 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P04759 (Residues: 22-516; Coverage: 100%)
Gene name: CHRND
Sequence domains:
Acetylcholine receptor subunit epsilon Chain: B
Molecule details ›
Chain: B
Length: 471 amino acids
Theoretical weight: 52.61 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P02715 (Residues: 21-491; Coverage: 100%)
Gene name: CHRNE
Sequence domains:
Toxin Chains: F, G
Molecule details ›
Chains: F, G
Length: 62 amino acids
Theoretical weight: 6.99 KDa
Source organism: synthetic construct
Expression system: Escherichia coli

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
2 bound ligands:
Ligand POV 8 x POV
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.09Å
Relevant EMDB volumes: EMD-43924
Expression system: Escherichia coli

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