› 9ayh

Electron Microscopy
3.1Å resolution

Cryo-EM structure of human Cav3.2 with TTA-A2

Released:
DOI: 10.2210/pdb9ayh/pdb
PDB entry 9ayh coloured by chain, front view.
PDB entry 9ayh coloured by chain, side view.
PDB entry 9ayh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for human Cav3.2 inhibition by selective antagonists.
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024)
PMID: 38605177
Related structures: EMD-43992

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-243415 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Voltage-dependent T-type calcium channel subunit alpha-1H Chain: A
Molecule details ›
Chain: A
Length: 2116 amino acids
Theoretical weight: 234.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O95180 (Residues: 1-2353; Coverage: 88%)
Gene name: CACNA1H
Sequence domains:

Ligands and Environments

6 bound ligands:
Ligand A1AHH 1 x A1AHH
Ligand NAG 2 x NAG
Ligand CA 1 x CA
Ligand LPE 1 x LPE
Ligand Y01 4 x Y01
Ligand JL3 4 x JL3
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-43992
Expression system: Homo sapiens

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