› 9az6

Electron Microscopy
2.98Å resolution

F-actin-Talin(R13-DD) complex

Released:
DOI: 10.2210/pdb9az6/pdb
PDB entry 9az6 coloured by chain, front view.
PDB entry 9az6 coloured by chain, side view.
PDB entry 9az6 coloured by chain, top view.
Source organisms:
Primary publication:
Biochemical and structural bases for talin ABSs-F-actin interactions
Biertumpfel C, Yamada Y, Vasquez-Montes V, Truong TV, Cada AK, Mizuno N
Proc. Natl. Acad. Sci. U.S.A. 122 (2025)
Related structures: EMD-44013

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tridecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-285212 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Actin, alpha skeletal muscle Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 375 amino acids
Theoretical weight: 41.88 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P68135 (Residues: 3-377; Coverage: 100%)
Gene names: ACTA, ACTA1
Sequence domains: Actin
Talin-1 Chains: F, G, H, I, J, K, L, M
Molecule details ›
Chains: F, G, H, I, J, K, L, M
Length: 246 amino acids
Theoretical weight: 26.11 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P26039 (Residues: 2301-2541; Coverage: 10%)
Gene names: Tln, Tln1
Sequence domains: I/LWEQ domain

Ligands and Environments

2 bound ligands:
Ligand ADP 5 x ADP
Ligand MG 5 x MG
1 modified residue:
Ligand HIC 5 x HIC

Experiments and Validation Details

Entry percentile scores
Resolution: 2.98Å
Relevant EMDB volumes: EMD-44013
Expression system: Escherichia coli BL21(DE3)

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