› 9b35

Electron Microscopy
3.4Å resolution

Ligand-binding and transmembrane domains of kainate receptor GluK2 in the open state, a complex with agonist glutamate and positive allosteric modulator BPAM344

Released:
DOI: 10.2210/pdb9b35/pdb
PDB entry 9b35 coloured by chain, front view.
PDB entry 9b35 coloured by chain, side view.
PDB entry 9b35 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Kainate receptor channel opening and gating mechanism.
Gangwar SP, Yelshanskaya MV, Nadezhdin KD, Yen LY, Newton TP, Aktolun M, Kurnikova MG, Sobolevsky AI
Nature (2024)
PMID: 38778115
Related structures: EMD-44128

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154587 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, kainate 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 912 amino acids
Theoretical weight: 102.98 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P42260 (Residues: 1-908; Coverage: 100%)
Gene names: Glur6, Grik2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand GLU 4 x GLU
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-44128
Expression system: Homo sapiens

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