› 9b38

Electron Microscopy
3.36Å resolution

Kainate receptor GluK2 in complex with agonist glutamate with pseudo 4-fold symmetrical ligand-binding domain layer

Released:
DOI: 10.2210/pdb9b38/pdb
PDB entry 9b38 coloured by chain, front view.
PDB entry 9b38 coloured by chain, side view.
PDB entry 9b38 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Kainate receptor channel opening and gating mechanism.
Gangwar SP, Yelshanskaya MV, Nadezhdin KD, Yen LY, Newton TP, Aktolun M, Kurnikova MG, Sobolevsky AI
Nature (2024)
PMID: 38778115
Related structures: EMD-44131

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154587 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
Glutamate receptor ionotropic, kainate 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 912 amino acids
Theoretical weight: 102.98 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P42260 (Residues: 1-908; Coverage: 100%)
Gene names: Glur6, Grik2
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand GLU 4 x GLU
Ligand NAG 18 x NAG
Ligand MAN 4 x MAN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.36Å
Relevant EMDB volumes: EMD-44131
Expression system: Homo sapiens

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