› 9b3s

X-ray diffraction
2.4Å resolution

Crystal structure of casein kinase 1 delta 1 with tethered phosphorylated tail

Released:
DOI: 10.2210/pdb9b3s/pdb
PDB entry 9b3s coloured by chain, front view.
PDB entry 9b3s coloured by chain, side view.
PDB entry 9b3s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Isoform-specific C-terminal phosphorylation drives autoinhibition of Casein kinase 1.
Harold RL, Tulsian NK, Narasimamurthy R, Yaitanes N, Ayala Hernandez MG, Lee HW, Crosby P, Tripathi SM, Virshup DM, Partch CL
Proc Natl Acad Sci U S A 121 e2415567121 (2024)
PMID: 39356670

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-546142 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase I isoform delta Chains: A, B
Molecule details ›
Chains: A, B
Length: 320 amino acids
Theoretical weight: 37.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P48730 (Residues: 1-415; Coverage: 77%)
Gene names: CSNK1D, HCKID
Sequence domains: Protein kinase domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand SEP 2 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: C2
Unit cell:
a: 55.452Å b: 135.117Å c: 90.602Å
α: 90° β: 94.36° γ: 90°
R-values:
R R work R free
0.199 0.196 0.247
Expression system: Escherichia coli

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