› 9b4g

Electron Microscopy
2.87Å resolution

Structure of inhibitor-bound human PSS1

Released:
DOI: 10.2210/pdb9b4g/pdb
PDB entry 9b4g coloured by chain, front view.
PDB entry 9b4g coloured by chain, side view.
PDB entry 9b4g coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular insights into human phosphatidylserine synthase 1 reveal its inhibition promotes LDL uptake.
Long T, Li D, Vale G, Jiang Y, Schmiege P, Yang ZJ, McDonald JG, Li X
Cell (2024)
PMID: 39208797
Related structures: EMD-44180

Function and Biology Details

Reaction catalysed: 
L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-546136 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylserine synthase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 409 amino acids
Theoretical weight: 48.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P48651 (Residues: 1-409; Coverage: 87%)
Gene names: KIAA0024, PSSA, PTDSS1
Sequence domains: Phosphatidyl serine synthase

Ligands and Environments

6 bound ligands:
Ligand P5S 4 x P5S
Ligand LBN 4 x LBN
Ligand A1AIS 2 x A1AIS
Ligand 6OU 2 x 6OU
Ligand CA 2 x CA
Ligand A1AIT 2 x A1AIT
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.87Å
Relevant EMDB volumes: EMD-44180
Expression system: Homo sapiens

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