› 9b6e

Electron Microscopy
2.91Å resolution

Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist TC-I 2014

Released:
DOI: 10.2210/pdb9b6e/pdb
PDB entry 9b6e coloured by chain, front view.
PDB entry 9b6e coloured by chain, side view.
PDB entry 9b6e coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8.
Yin Y, Park CG, Zhang F, G Fedor J, Feng S, Suo Y, Im W, Lee SY
Sci Adv 10 eadp2211 (2024)
PMID: 39093967
Related structures: EMD-44256

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185896 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily M member 8 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1135 amino acids
Theoretical weight: 131.55 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8R4D5 (Residues: 2-1104; Coverage: 100%)
Gene names: Ltrpc6, Trpm8, Trpp8
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand T14 4 x T14
Ligand Y01 16 x Y01
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.91Å
Relevant EMDB volumes: EMD-44256
Expression system: Homo sapiens

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