› 9b79

Electron Microscopy
2.71Å resolution

Mycobacterium tuberculosis CoaX Homotetramer

Released:
DOI: 10.2210/pdb9b79/pdb
PDB entry 9b79 coloured by chain, front view.
PDB entry 9b79 coloured by chain, side view.
PDB entry 9b79 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
Identification of a depupylation regulator for an essential enzyme in Mycobacterium tuberculosis.
Kahne SC, Yoo JH, Chen J, Nakedi K, Iyer LM, Putzel G, Samhadaneh NM, Pironti A, Aravind L, Ekiert DC, Bhabha G, Rhee KY, Darwin KH
Proc Natl Acad Sci U S A 121 e2407239121 (2024)
PMID: 39585979
Related structures: EMD-44304

Function and Biology Details

Reaction catalysed: 
ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-283272 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Type III pantothenate kinase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 272 amino acids
Theoretical weight: 29.34 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WPA1 (Residues: 1-272; Coverage: 100%)
Gene names: Rv3600c, coaX
Sequence domains: Type III pantothenate kinase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.71Å
Relevant EMDB volumes: EMD-44304
Expression system: Escherichia coli

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