› 9b90

Electron Microscopy
3.4Å resolution

Cryo-EM structure of the human TRPM4 channel in complex with calcium and ATP at 37 degrees Celsius

Released:
DOI: 10.2210/pdb9b90/pdb
PDB entry 9b90 coloured by chain, front view.
PDB entry 9b90 coloured by chain, side view.
PDB entry 9b90 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Physiological temperature drives TRPM4 ligand recognition and gating.
Hu J, Park SJ, Walter T, Orozco IJ, O'Dea G, Ye X, Du J, Lü W
Nature (2024)
PMID: 38750366
Related structures: EMD-44364

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186204 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily M member 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1214 amino acids
Theoretical weight: 134.46 KDa
Source organism: Homo sapiens
Expression system: Mammalia
UniProt:
  • Canonical: Q8TD43 (Residues: 1-1214; Coverage: 100%)
Gene names: LTRPC4, TRPM4
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand CA 8 x CA
Ligand ATP 4 x ATP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-44364
Expression system: Mammalia

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