9bew

Electron Microscopy
3.3Å resolution

Cryo-EM structure of the HIV-1 BG505 IDL Env trimer in complex with 3BNC117 and 10-1074 Fabs

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero octadecamer (preferred)
PDBe Complex ID:
PDB-CPX-247768 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (11 distinct):
Envelope glycoprotein gp120 Chains: A, G, M
Molecule details ›
Chains: A, G, M
Length: 483 amino acids
Theoretical weight: 54.12 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
Envelope glycoprotein gp41 Chains: B, E, N
Molecule details ›
Chains: B, E, N
Length: 153 amino acids
Theoretical weight: 17.11 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
3BNC117 heavy chain Chains: C, F, O
Molecule details ›
Chains: C, F, O
Length: 226 amino acids
Theoretical weight: 24.66 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
3BNC117 light chain Chains: D, I, P
Molecule details ›
Chains: D, I, P
Length: 206 amino acids
Theoretical weight: 23.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
10-1074 heavy chain Chains: H, J, Q
Molecule details ›
Chains: H, J, Q
Length: 235 amino acids
Theoretical weight: 25.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
10-1074 light chain Chains: K, L, R
Molecule details ›
Chains: K, L, R
Length: 214 amino acids
Theoretical weight: 23.18 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-44484
Expression system: Homo sapiens