› 9bj2

Electron Microscopy
2.8Å resolution

Structure of the SARS-CoV-2 S 6P trimer complex with the human neutralizing antibody Fab fragment, C1533 (local refinement of NTD and C1533)

Released:
DOI: 10.2210/pdb9bj2/pdb
PDB entry 9bj2 coloured by chain, front view.
PDB entry 9bj2 coloured by chain, side view.
PDB entry 9bj2 coloured by chain, top view.
Source organisms:
Primary publication:
Bispecific antibodies targeting the N-terminal and receptor binding domains potently neutralize SARS-CoV-2 variants of concern.
Rubio AA, Baharani VA, Dadonaite B, Parada M, Abernathy ME, Wang Z, Lee YE, Eso MR, Phung J, Ramos I, Chen T, El Nesr G, Bloom JD, Bieniasz PD, Nussenzweig MC, Barnes CO
Sci Transl Med 17 eadq5720 (2025)
PMID: 40043139
Related structures: EMD-44627

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-287680 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Spike glycoprotein Chain: A
Molecule details ›
Chain: A
Length: 1288 amino acids
Theoretical weight: 142.43 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1208; Coverage: 95%)
Gene names: 2, S
Sequence domains:
C1533 Heavy Chain Chain: H
Molecule details ›
Chain: H
Length: 261 amino acids
Theoretical weight: 28.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
C1533 Light Chain Chain: L

Ligands and Environments

1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.8Å
Relevant EMDB volumes: EMD-44627
Expression system: Homo sapiens

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