› 9bjk

Electron Microscopy
3.26Å resolution

Inactive mu opioid receptor bound to Nb6, naloxone and NAM

Released:
DOI: 10.2210/pdb9bjk/pdb
PDB entry 9bjk coloured by chain, front view.
PDB entry 9bjk coloured by chain, side view.
PDB entry 9bjk coloured by chain, top view.
Source organisms:
Primary publication:
A µ-opioid receptor modulator that works cooperatively with naloxone.
O'Brien ES, Rangari VA, El Daibani A, Eans SO, Hammond HR, White E, Wang H, Shiimura Y, Krishna Kumar K, Jiang Q, Appourchaux K, Huang W, Zhang C, Kennedy BJ, Mathiesen JM, Che T, McLaughlin JP, Majumdar S, Kobilka BK
Nature (2024)
PMID: 38961287
Related structures: EMD-44635

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-273752 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
kappa opioid receptor Nanobody 6 Chain: N
Molecule details ›
Chain: N
Length: 133 amino acids
Theoretical weight: 14.73 KDa
Source organism: Lama glama
Expression system: Escherichia coli
Mu-type opioid receptor Chain: R
Molecule details ›
Chain: R
Length: 426 amino acids
Theoretical weight: 47.92 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda

Ligands and Environments

2 bound ligands:
Ligand A1APV 1 x A1APV
Ligand A1APU 1 x A1APU
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.26Å
Relevant EMDB volumes: EMD-44635
Expression systems:
  • Escherichia coli
  • Spodoptera frugiperda

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