9bvp

Electron Microscopy
3.3Å resolution

Vitamin K-dependent gamma-carboxylase with TMG2 propeptide and glutamate-rich region and with vitamin K hydroquinone

Released:
Source organism: Homo sapiens
Entry authors: Li W, Liu B, Cao Q
Related structures: EMD-44940

Function and Biology Details

Reaction catalysed:
[Peptidyl]-4-carboxyglutamate + 2,3-epoxyphylloquinone + H(2)O = [peptidyl]-glutamate + CO(2) + O(2) + phylloquinol
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-284152 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Vitamin K-dependent gamma-carboxylase Chain: A
Molecule details ›
Chain: A
Length: 733 amino acids
Theoretical weight: 85.09 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P38435 (Residues: 26-758; Coverage: 97%)
Gene names: GC, GGCX
Sequence domains:
Transmembrane gamma-carboxyglutamic acid protein 2 Chain: P
Molecule details ›
Chain: P
Length: 116 amino acids
Theoretical weight: 13.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O14669 (Residues: 24-139; Coverage: 65%)
Gene names: PRGP2, PRRG2, TMG2
Sequence domains: Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
3 bound ligands:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.3Å
Relevant EMDB volumes: EMD-44940
Expression system: Homo sapiens