› 9bxr

Electron Microscopy
3.2Å resolution

Straight Filaments purified from Down Syndrome individual brain tissue applied to graphene oxide antibody affinity grids

Released:
DOI: 10.2210/pdb9bxr/pdb
PDB entry 9bxr coloured by chain, front view.
PDB entry 9bxr coloured by chain, side view.
PDB entry 9bxr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold.
Ghosh U, Tse E, Yang H, Shi M, Caro CD, Wang F, Merz GE, Prusiner SB, Southworth DR, Condello C
Acta Neuropathol Commun 12 94 (2024)
PMID: 38867338
Related structures: EMD-45009

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145403 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microtubule-associated protein tau Chains: C, D, E, F, G, H
Molecule details ›
Chains: C, D, E, F, G, H
Length: 77 amino acids
Theoretical weight: 8.37 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P10636 (Residues: 621-697; Coverage: 10%)
Gene names: MAPT, MAPTL, MTBT1, TAU
Sequence domains: Tau and MAP protein, tubulin-binding repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-45009

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