› 9c49

Electron Microscopy
2.97Å resolution

Cryo-EM structure of Danio rerio voltage-sensing phosphatase (VSP) phosphatase domain

Released:
DOI: 10.2210/pdb9c49/pdb
PDB entry 9c49 coloured by chain, front view.
PDB entry 9c49 coloured by chain, side view.
PDB entry 9c49 coloured by chain, top view.
Source organism: Danio rerio
Primary publication:
Coupling sensor to enzyme in the voltage sensing phosphatase.
Yu Y, Zhang L, Li B, Fu Z, Brohawn SG, Isacoff EY
Nat Commun 15 6409 (2024)
PMID: 39080263
Related structures: EMD-45178

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-246997 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Chains: A, B
Molecule details ›
Chains: A, B
Length: 520 amino acids
Theoretical weight: 59.64 KDa
Source organism: Danio rerio
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q4V9E4 (Residues: 1-511; Coverage: 100%)
Gene names: tpip, tpte, vsp, wu:fd20e11, wu:fi24b06
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.97Å
Relevant EMDB volumes: EMD-45178
Expression system: Komagataella pastoris

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