› 9c55

X-ray diffraction
2.36Å resolution

Crystal structure of human PTPN2 in complex with active site inhibitor

Released:
DOI: 10.2210/pdb9c55/pdb
PDB entry 9c55 coloured by chain, front view.
PDB entry 9c55 coloured by chain, side view.
PDB entry 9c55 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Enhancing the apo protein tyrosine phosphatase non-receptor type 2 crystal soaking strategy through inhibitor-accessible binding sites.
Bester SM, Linwood R, Kataoka R, Wu WI, Mou TC
Acta Crystallogr F Struct Biol Commun (2024)
PMID: 39177701

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148138 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 2 Chain: A
Molecule details ›
Chain: A
Length: 315 amino acids
Theoretical weight: 36.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P17706 (Residues: 1-314; Coverage: 76%)
Gene names: PTPN2, PTPT
Sequence domains: Protein-tyrosine phosphatase

Ligands and Environments

1 bound ligand:
Ligand 527 1 x 527
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: C2221
Unit cell:
a: 83.392Å b: 223.052Å c: 36.585Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.199 0.234
Expression system: Escherichia coli

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