› 9c6r

Electron Microscopy
3.2Å resolution

Blood cell-specific tubulin in complex with Cryptophycin-52

Released:
DOI: 10.2210/pdb9c6r/pdb
PDB entry 9c6r coloured by chain, front view.
PDB entry 9c6r coloured by chain, side view.
PDB entry 9c6r coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Structure of blood cell-specific tubulin and demonstration of dimer spacing compaction in a single protofilament.
Montecinos F, Eren E, Watts NR, Sackett DL, Wingfield PT
J Biol Chem 108132 (2024)
PMID: 39725029
Related structures: EMD-45263

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-283849 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tubulin alpha-1A chain Chains: A, F, K, P, U, Z, e, j
Molecule details ›
Chains: A, F, K, P, U, Z, e, j
Length: 451 amino acids
Theoretical weight: 50.19 KDa
Source organism: Gallus gallus
UniProt:
  • Canonical: P02552 (Residues: 1-451; Coverage: 100%)
Gene name: TUBA1A
Sequence domains:
Tubulin beta-6 chain Chains: B, G, L, Q, V, a, f, k
Molecule details ›
Chains: B, G, L, Q, V, a, f, k
Length: 446 amino acids
Theoretical weight: 50.2 KDa
Source organism: Gallus gallus
UniProt:
  • Canonical: P09207 (Residues: 1-446; Coverage: 100%)
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand GTP 8 x GTP
Ligand YGY 8 x YGY
Ligand GDP 8 x GDP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-45263

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