› 9c8s

Electron Microscopy
2.37Å resolution

CryoEM structure of Cryptococcus neoformans H99 Acetyl-CoA Synthetase in complex with adenosine-5'-ethylphosphate

Released:
DOI: 10.2210/pdb9c8s/pdb
PDB entry 9c8s coloured by chain, front view.
PDB entry 9c8s coloured by chain, side view.
PDB entry 9c8s coloured by chain, top view.
Source organism: Cryptococcus neoformans var. grubii H99
Entry authors: Xu Z, Schnicker NJ, Jezeski AJ, Krysan DJ
Related structures: EMD-45309

Function and Biology Details

Reaction catalysed: 
ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125412 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acetyl-coenzyme A synthetase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 694 amino acids
Theoretical weight: 77.48 KDa
Source organism: Cryptococcus neoformans var. grubii H99
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: J9VFT1 (Residues: 2-680; Coverage: 100%)
Gene name: CNAG_00797
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand WTA 3 x WTA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.37Å
Relevant EMDB volumes: EMD-45309
Expression system: Escherichia coli BL21(DE3)

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