› 9c96

Electron Microscopy
3Å resolution

Cryo-EM structure of TAP binding protein related (TAPBPR) in complex with HLA-A*02:01 bound to a suboptimal peptide.

Released:
DOI: 10.2210/pdb9c96/pdb
PDB entry 9c96 coloured by chain, front view.
PDB entry 9c96 coloured by chain, side view.
PDB entry 9c96 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
CryoEM structure of an MHC-I/TAPBPR peptide-bound intermediate reveals the mechanism of antigen proofreading.
Sun Y, Pumroy RA, Mallik L, Chaudhuri A, Wang C, Hwang D, Danon JN, Dasteh Goli K, Moiseenkova-Bell VY, Sgourakis NG
Proc Natl Acad Sci U S A 122 e2416992122 (2025)
PMID: 39786927
Related structures: EMD-45360

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-284956 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 277 amino acids
Theoretical weight: 32.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 98 amino acids
Theoretical weight: 11.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Tapasin-related protein Chain: C
LYS-ILE-LEU-GLY-PHE-VAL Chain: D

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3Å
Relevant EMDB volumes: EMD-45360
Expression systems:
  • Escherichia coli
  • Not provided

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