› 9chr

Electron Microscopy
3.5Å resolution

Cryo-EM structure of the human ether-a-go-go related K+ channel (hERG) in 300 mM K+ without symmetry

Released:
DOI: 10.2210/pdb9chr/pdb
PDB entry 9chr coloured by chain, front view.
PDB entry 9chr coloured by chain, side view.
PDB entry 9chr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Potassium dependent structural changes in the selectivity filter of HERG potassium channels.
Lau CHY, Flood E, Hunter MJ, Williams-Noonan BJ, Corbett KM, Ng CA, Bouwer JC, Stewart AG, Perozo E, Allen TW, Vandenberg JI
Nat Commun 15 7470 (2024)
PMID: 39209832
Related structures: EMD-45599

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171400 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Voltage-gated inwardly rectifying potassium channel KCNH2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 784 amino acids
Theoretical weight: 87.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q12809 (Residues: 1-1159; Coverage: 68%)
  • Best match: Q12809-6 (Residues: 32-460)
Gene names: ERG, ERG1, HERG, KCNH2
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-45599
Expression system: Homo sapiens

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