› 9cpj

Solution NMR

Structures of small molecules bound to RNA repeat expansions that cause Huntington's disease-like 2 and myotonic dystrophy type 1

Released:
DOI: 10.2210/pdb9cpj/pdb
PDB entry 9cpj coloured by chain, ensemble of 20 models, front view.
PDB entry 9cpj coloured by chain, ensemble of 20 models, side view.
PDB entry 9cpj coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structures of small molecules bound to RNA repeat expansions that cause Huntington's disease-like 2 and myotonic dystrophy type 1.
Chen JL, Taghavi A, Frank AJ, Fountain MA, Choudhary S, Roy S, Childs-Disney JL, Disney MD
Bioorg Med Chem Lett 129888 (2024)
PMID: 39002937

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-249382 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
RNA (5'-R(*GP*AP*CP*AP*GP*CP*UP*GP*CP*UP*GP*UP*C)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 13 nucleotides
Theoretical weight: 4.13 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 21%
Refinement method: simulated annealing
Expression system: Not provided

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