› 9cuh

Electron Microscopy
3.03Å resolution

Structure of human full-length ancestral TRPV6 channel in apo open state

Released:
DOI: 10.2210/pdb9cuh/pdb
PDB entry 9cuh coloured by chain, front view.
PDB entry 9cuh coloured by chain, side view.
PDB entry 9cuh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-function analyses of human TRPV6 ancestral and derived haplotypes.
Neuberger A, Shalygin A, Trofimov YA, Veretenenko II, Nadezhdin KD, Krylov NA, Gudermann T, Efremov RG, Chubanov V, Sobolevsky AI
Structure (2024)
PMID: 39500315
Related structures: EMD-45933

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190512 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 6 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 765 amino acids
Theoretical weight: 87.38 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9H1D0 (Residues: 1-765; Coverage: 100%)
Gene names: ECAC2, TRPV6
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand Y01 12 x Y01
Ligand PCW 4 x PCW
Ligand POV 32 x POV
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.03Å
Relevant EMDB volumes: EMD-45933
Expression system: Homo sapiens

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