› 9cui

Electron Microscopy
3.42Å resolution

Structure of human full-length ancestral TRPV6 channel in Calmodulin-bound state

Released:
DOI: 10.2210/pdb9cui/pdb
PDB entry 9cui coloured by chain, front view.
PDB entry 9cui coloured by chain, side view.
PDB entry 9cui coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-function analyses of human TRPV6 ancestral and derived haplotypes.
Neuberger A, Shalygin A, Trofimov YA, Veretenenko II, Nadezhdin KD, Krylov NA, Gudermann T, Efremov RG, Chubanov V, Sobolevsky AI
Structure (2024)
PMID: 39500315
Related structures: EMD-45934

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143959 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transient receptor potential cation channel subfamily V member 6 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 765 amino acids
Theoretical weight: 87.38 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9H1D0 (Residues: 1-765; Coverage: 100%)
Gene names: ECAC2, TRPV6
Sequence domains:
Calmodulin-1 Chain: E
Molecule details ›
Chain: E
Length: 149 amino acids
Theoretical weight: 16.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DP23 (Residues: 1-149; Coverage: 100%)
Gene names: CALM, CALM1, CAM, CAM1
Sequence domains: EF-hand domain pair

Ligands and Environments

4 bound ligands:
Ligand Y01 8 x Y01
Ligand CLR 4 x CLR
Ligand PCW 43 x PCW
Ligand CA 7 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.42Å
Relevant EMDB volumes: EMD-45934
Expression system: Homo sapiens

Quick links