› 9cux

X-ray diffraction
1.27Å resolution

Crystal Structure of SETDB1 Tudor domain in complex with UNC100016

Released:
DOI: 10.2210/pdb9cux/pdb
PDB entry 9cux coloured by chain, front view.
PDB entry 9cux coloured by chain, side view.
PDB entry 9cux coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Silva M, Dong A, Arrowsmith CH, Edwards AM, Halabelian L, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
S-adenosyl-L-methionine + a [histone H3]-N(6),N(6)-dimethyl-L-lysine(9) = S-adenosyl-L-homocysteine + a [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine(9)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172172 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone-lysine N-methyltransferase SETDB1 Chain: A
Molecule details ›
Chain: A
Length: 225 amino acids
Theoretical weight: 26.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15047 (Residues: 196-403; Coverage: 16%)
Gene names: ESET, KIAA0067, KMT1E, SETDB1
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand A1AZ5 1 x A1AZ5
Ligand SO4 2 x SO4
Ligand EDO 9 x EDO
Ligand UNX 4 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08B1-1
Spacegroup: P212121
Unit cell:
a: 52.834Å b: 60.663Å c: 70.007Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.16 0.159 0.181
Expression system: Escherichia coli

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