› 9cxj

Electron Microscopy
3.1Å resolution

Structure of PDE6C in complex with the rod inhibitory p gamma subunit with disordered GafA region

Released:
DOI: 10.2210/pdb9cxj/pdb
PDB entry 9cxj coloured by chain, front view.
PDB entry 9cxj coloured by chain, side view.
PDB entry 9cxj coloured by chain, top view.
Source organisms:
Primary publication:
Structural and functional dynamics of human cone cGMP-phosphodiesterase important for photopic vision.
Singh S, Srivastava D, Boyd K, Artemyev NO
Proc Natl Acad Sci U S A 122 e2419732121 (2025)
PMID: 39739818
Related structures: EMD-45993

Function and Biology Details

Reaction catalysed: 
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-282794 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' Chains: A, B
Molecule details ›
Chains: A, B
Length: 843 amino acids
Theoretical weight: 97.72 KDa
Source organism: Homo sapiens
Expression system: Spodoptera aff. frugiperda 1 BOLD-2017
UniProt:
  • Canonical: P51160 (Residues: 2-830; Coverage: 97%)
Gene names: PDE6C, PDEA2
Sequence domains:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma Chains: C, D
Molecule details ›
Chains: C, D
Length: 99 amino acids
Theoretical weight: 11.06 KDa
Source organism: Bos taurus
Expression system: Spodoptera aff. frugiperda 1 BOLD-2017
UniProt:
  • Canonical: P04972 (Residues: 1-87; Coverage: 100%)
Gene names: PDE6G, PDEG
Sequence domains: Retinal cGMP phosphodiesterase, gamma subunit

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-45993
Expression system: Spodoptera aff. frugiperda 1 BOLD-2017

Quick links