› 9czl

Electron Microscopy
2.9Å resolution

Straight tau filaments in dominantly inherited Alzheimer disease with cotton wool plaques

Released:
DOI: 10.2210/pdb9czl/pdb
PDB entry 9czl coloured by chain, front view.
PDB entry 9czl coloured by chain, side view.
PDB entry 9czl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of cotton wool plaques' amyloid β and of tau filaments in dominantly inherited Alzheimer disease.
Hoq MR, Fernandez A, Vago FS, Hallinan GI, Bharath SR, Li D, Ozcan KA, Garringer HJ, Jiang W, Vidal R, Ghetti B
Acta Neuropathol 148 20 (2024)
PMID: 39147931
Related structures: EMD-46420

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145394 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microtubule-associated protein tau Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 74 amino acids
Theoretical weight: 8.07 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P10636 (Residues: 622-695; Coverage: 10%)
  • Best match: P10636-2 (Residues: 216-289)
Gene names: MAPT, MAPTL, MTBT1, TAU
Sequence domains: Tau and MAP protein, tubulin-binding repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-46420

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