› 9czn

Electron Microscopy
2.6Å resolution

Type Ic amyloid-beta 42 filaments in dominantly inherited Alzheimer disease with cotton wool plaques

Released:
DOI: 10.2210/pdb9czn/pdb
PDB entry 9czn coloured by chain, front view.
PDB entry 9czn coloured by chain, side view.
PDB entry 9czn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of cotton wool plaques' amyloid β and of tau filaments in dominantly inherited Alzheimer disease.
Hoq MR, Fernandez A, Vago FS, Hallinan GI, Bharath SR, Li D, Ozcan KA, Garringer HJ, Jiang W, Vidal R, Ghetti B
Acta Neuropathol 148 20 (2024)
PMID: 39147931
Related structures: EMD-46422

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo icosamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-242570 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid-beta protein 40 Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T
Length: 34 amino acids
Theoretical weight: 3.56 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P05067 (Residues: 680-713; Coverage: 5%)
Gene names: A4, AD1, APP
Sequence domains: Beta-amyloid peptide (beta-APP)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.6Å
Relevant EMDB volumes: EMD-46422

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