› 9czo

Electron Microscopy
2.87Å resolution

Ca2+ bound intermediate state of hSlo1 + beta2N-beta4 channel in nanodisc.

Released:
DOI: 10.2210/pdb9czo/pdb
PDB entry 9czo coloured by chain, front view.
PDB entry 9czo coloured by chain, side view.
PDB entry 9czo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Ball-and-chain inactivation of a human large conductance calcium-activated potassium channel.
Agarwal S, Kim ED, Lee S, Simon A, Accardi A, Nimigean CM
Nat Commun 16 1769 (2025)
PMID: 39971906
Related structures: EMD-46423

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-286942 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Calcium-activated potassium channel subunit alpha-1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1056 amino acids
Theoretical weight: 118.97 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q12791 (Residues: 66-1179; Coverage: 85%)
  • Best match: Q12791-5 (Residues: 66-1121)
Gene names: KCNMA, KCNMA1, SLO
Sequence domains:
Calcium-activated potassium channel subunit beta-4; KCNMB2 ball/chain domain-containing protein Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 239 amino acids
Theoretical weight: 27.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: B5BNX0 (Residues: 2-45; Coverage: 77%)
  • Canonical: Q86W47 (Residues: 16-210; Coverage: 93%)
Gene names: KCNMB2, KCNMB4
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand CA 8 x CA
Ligand K 4 x K
Ligand POV 11 x POV
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.87Å
Relevant EMDB volumes: EMD-46423
Expression system: Homo sapiens

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