› 9d12

X-ray diffraction
2.1Å resolution

Smarca2 Bromodomain in complex with compound 15

Released:
DOI: 10.2210/pdb9d12/pdb
Model geometry
Fit model/data
PDB entry 9d12 coloured by chain, front view.
PDB entry 9d12 coloured by chain, side view.
PDB entry 9d12 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery of High-Affinity SMARCA2/4 Bromodomain Ligands and Development of Potent and Exceptionally Selective SMARCA2 PROTAC Degraders.
Leng L, Tu W, Yang L, Huang L, Wang M, Meagher JL, Chinnaswamy K, Allu SR, Rej RK, Tošović J, Harikrishnan L, Li Z, Sui Z, Stuckey JA, Wang S
J Med Chem (2025)
PMID: 39745064

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156349 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Probable global transcription activator SNF2L2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 124 amino acids
Theoretical weight: 14.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51531 (Residues: 1373-1511; Coverage: 8%)
  • Best match: P51531-2 (Residues: 1373-1493)
Gene names: BAF190B, BRM, SMARCA2, SNF2A, SNF2L2
Sequence domains: Bromodomain

Ligands and Environments

3 bound ligands:
Ligand ZN 3 x ZN
Ligand A1A1P 3 x A1A1P
Ligand ACT 3 x ACT
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P31
Unit cell:
a: 67.897Å b: 67.897Å c: 88.819Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.217 0.216 0.24
Expression system: Escherichia coli

Quick links