› 9d6c

Electron Microscopy
2.1Å resolution

Gag CA-SP1 immature lattice bound with Lenacapavir and Bevirimat from enveloped virus like particles

Released:
DOI: 10.2210/pdb9d6c/pdb
PDB entry 9d6c coloured by chain, front view.
PDB entry 9d6c coloured by chain, side view.
PDB entry 9d6c coloured by chain, top view.
Source organism: HIV-1 M:B_HXB2R
Primary publication:
Structural insights into inhibitor mechanisms on immature HIV-1 Gag lattice revealed by high-resolution in situ single-particle cryo-EM.
Wu C, Meuser ME, Rey JS, Meshkin H, Yang R, Devarkar SC, Freniere C, Shi J, Aiken C, Perilla JR, Xiong Y
bioRxiv (2024)
PMID: 39416065
Related structures: EMD-46593

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo octadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138041 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein p24 Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R
Length: 232 amino acids
Theoretical weight: 25.7 KDa
Source organism: HIV-1 M:B_HXB2R
Expression system: Homo sapiens
UniProt:
  • Canonical: P04591 (Residues: 141-372; Coverage: 46%)
Gene name: gag
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand QNG 18 x QNG
Ligand 2I4 7 x 2I4
Ligand IHP 7 x IHP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.1Å
Relevant EMDB volumes: EMD-46593
Expression system: Homo sapiens

Quick links

Citations

1 mention without citation

Structural insights into inhibitor mechanisms on immature HIV-1 Gag lattice revealed by high-resolution <i>in situ</i> single-particle cryo-EM.
Wu et al. (2024)