› 9dyi

Electron Microscopy
3.03Å resolution

BEST2 + glutamate closed state

Released:
DOI: 10.2210/pdb9dyi/pdb
PDB entry 9dyi coloured by chain, front view.
PDB entry 9dyi coloured by chain, side view.
PDB entry 9dyi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Neurotransmitter-bound bestrophin channel structures reveal small molecule drug targeting sites for disease treatment.
Owji AP, Dong J, Kittredge A, Wang J, Zhang Y, Yang T
Nat Commun 15 10766 (2024)
PMID: 39737942
Related structures: EMD-47305

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185538 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bestrophin-2a Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 509 amino acids
Theoretical weight: 57.19 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8NFU1 (Residues: 1-509; Coverage: 100%)
Gene names: BEST2, VMD2L1
Sequence domains: Bestrophin, RFP-TM, chloride channel

Ligands and Environments

3 bound ligands:
Ligand GLU 5 x GLU
Ligand CA 5 x CA
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.03Å
Relevant EMDB volumes: EMD-47305
Expression system: Homo sapiens

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