› 9dz2

Electron Microscopy
3.31Å resolution

Cryo-EM structure of Sudan ebolavirus glycoprotein complexed with hNPC1-C

Released:
DOI: 10.2210/pdb9dz2/pdb
PDB entry 9dz2 coloured by chain, front view.
PDB entry 9dz2 coloured by chain, side view.
PDB entry 9dz2 coloured by chain, top view.
Source organisms:
Primary publication:
Cryo-EM structure of Sudan ebolavirus glycoprotein complexed with its human endosomal receptor NPC1.
Bu F, Ye G, Turner-Hubbard H, Herbst M, Liu B, Li F
Commun Biol 8 156 (2025)
PMID: 39894818
Related structures: EMD-47323

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-286506 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
NPC intracellular cholesterol transporter 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 280 amino acids
Theoretical weight: 31.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O15118 (Residues: 374-620; Coverage: 20%)
Gene name: NPC1
Sequence domains: NPC1, middle luminal domain
GP1 Chains: A, E, I
Molecule details ›
Chains: A, E, I
Length: 195 amino acids
Theoretical weight: 21.55 KDa
Source organism: Sudan ebolavirus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q7T9D9 (Residues: 1-195; Coverage: 25%)
Gene name: GP
Sequence domains: Filovirus glycoprotein
Shed GP Chains: B, F, J

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.31Å
Relevant EMDB volumes: EMD-47323
Expression system: Homo sapiens

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