› 9e6s

X-ray diffraction
2.2Å resolution

BCL11A ZF4-6 with K784T Mutation in Complex with a DNA Sequence Observed in the Human Globin Locus Containing Motif TGACCA

Released:
DOI: 10.2210/pdb9e6s/pdb
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PDB entry 9e6s coloured by chain, front view.
PDB entry 9e6s coloured by chain, side view.
PDB entry 9e6s coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Horton JR, Cheng X

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-291558 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
B-cell lymphoma/leukemia 11A Chains: A, D
Molecule details ›
Chains: A, D
Length: 108 amino acids
Theoretical weight: 12.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H165 (Residues: 730-835; Coverage: 13%)
Gene names: BCL11A, CTIP1, EVI9, KIAA1809, ZNF856
Sequence domains: Zinc finger, C2H2 type
DNA Strand I Chain: B
Molecule details ›
Chain: B
Length: 20 nucleotides
Theoretical weight: 6.2 KDa
Source organism: Homo sapiens
Expression system: Not provided
DNA Strand II Chain: C

Ligands and Environments

2 bound ligands:
Ligand EDO 1 x EDO
Ligand ZN 6 x ZN
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: NSLS-II BEAMLINE 17-ID-1
Spacegroup: P41212
Unit cell:
a: 59.464Å b: 59.464Å c: 246.988Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.241 0.275
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

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