› 9eih

Electron Microscopy
3.1Å resolution

Import stalled PINK1 TOM complex

Released:
DOI: 10.2210/pdb9eih/pdb
PDB entry 9eih coloured by chain, front view.
PDB entry 9eih coloured by chain, side view.
PDB entry 9eih coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human PINK1 at a mitochondrial TOM-VDAC array
Callegari S, Kirk NS, Gan ZY, Cobbold SA, Dite T, Leis A, Dagley LF, Glukhova A, Komander D
Science (2025)
Related structures: EMD-48083

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero 26-mer (preferred)
PDBe Complex ID:
PDB-CPX-289445 (preferred)
Entry contents:
8 distinct polypeptide molecules
Macromolecules (8 distinct):
Mitochondrial import receptor subunit TOM20 homolog Chains: C, D
Molecule details ›
Chains: C, D
Length: 145 amino acids
Theoretical weight: 16.32 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q15388 (Residues: 1-145; Coverage: 100%)
Gene names: KIAA0016, TOMM20
Sequence domains: MAS20 protein import receptor
Non-selective voltage-gated ion channel VDAC2 Chains: E, F
Molecule details ›
Chains: E, F
Length: 294 amino acids
Theoretical weight: 31.6 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P45880 (Residues: 1-294; Coverage: 100%)
Gene name: VDAC2
Sequence domains: Eukaryotic porin
Mitochondrial import receptor subunit TOM40 homolog Chains: G, H, I, J
Mitochondrial import receptor subunit TOM5 homolog Chains: K, L, Y, Z
Mitochondrial import receptor subunit TOM7 homolog Chains: M, N, W, X
Mitochondrial import receptor subunit TOM6 homolog Chains: O, P, U, V
Mitochondrial import receptor subunit TOM22 homolog Chains: Q, R, S, T
Serine/threonine-protein kinase PINK1, mitochondrial Chains: A, B

Ligands and Environments

1 bound ligand:
Ligand PC1 17 x PC1
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.1Å
Relevant EMDB volumes: EMD-48083
Expression system: Homo sapiens

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