› 9erf

Electron Microscopy
2.64Å resolution

SLFN11 dimer bound to tRNA-Met-CAT

Released:
DOI: 10.2210/pdb9erf/pdb
PDB entry 9erf coloured by chain, front view.
PDB entry 9erf coloured by chain, side view.
PDB entry 9erf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Phosphorylation-mediated conformational change regulates human SLFN11.
Kugler M, Metzner FJ, Witte G, Hopfner KP, Lammens K
Nat Commun 15 10500 (2024)
PMID: 39627193
Related structures: EMD-19914

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-283346 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct RNA molecules
Macromolecules (3 distinct):
Schlafen family member 11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 929 amino acids
Theoretical weight: 106.21 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q7Z7L1 (Residues: 1-901; Coverage: 100%)
Gene name: SLFN11
Sequence domains:
RNA (65-MER) Chain: T
Molecule details ›
Chain: T
Length: 65 nucleotides
Theoretical weight: 21.09 KDa
Source organism: Homo sapiens
Expression system: Not provided
RNA (5'-R(P*UP*CP*UP*GP*CP*UP*AP*CP*CP*A)-3') Chain: U
Molecule details ›
Chain: U
Length: 10 nucleotides
Theoretical weight: 3.1 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

3 bound ligands:
Ligand ZN 2 x ZN
Ligand MN 3 x MN
Ligand MG 3 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.64Å
Relevant EMDB volumes: EMD-19914
Expression systems:
  • Trichoplusia ni
  • Not provided

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