› 9ern

Electron Microscopy
2.5Å resolution

CTE type II tau filament from vacuolar tauopathy

Released:
DOI: 10.2210/pdb9ern/pdb
PDB entry 9ern coloured by chain, front view.
PDB entry 9ern coloured by chain, side view.
PDB entry 9ern coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Tau filaments with the chronic traumatic encephalopathy fold in a case of vacuolar tauopathy with VCP mutation D395G.
Qi C, Kobayashi R, Kawakatsu S, Kametani F, Scheres SHW, Goedert M, Hasegawa M
OpenAccess logo Acta Neuropathol 147 86 (2024)
PMID: 38758288
Related structures: EMD-19927

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145403 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microtubule-associated protein tau Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 441 amino acids
Theoretical weight: 45.92 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P10636 (Residues: 1-758; Coverage: 58%)
  • Best match: P10636-8 (Residues: 1-441)
Gene names: MAPT, MAPTL, MTBT1, TAU
Sequence domains: Tau and MAP protein, tubulin-binding repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.5Å
Relevant EMDB volumes: EMD-19927

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