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X-ray diffraction
2.61Å resolution

Apo human TDO in complex with a bound inhibitor (Cpd-4)

Released:
Model geometry
Fit model/data

Function and Biology Details

Reaction catalysed:
L-tryptophan + O(2) = N-formyl-L-kynurenine
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
PDBe Complex ID:
PDB-CPX-155809 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tryptophan 2,3-dioxygenase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 403 amino acids
Theoretical weight: 47.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P48775 (Residues: 19-406; Coverage: 96%)
Gene names: TDO, TDO2
Sequence domains: Tryptophan 2,3-dioxygenase

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P21212
Unit cell:
a: 133.793Å b: 156.159Å c: 90.655Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.3 0.298 0.33
Expression system: Escherichia coli