› 9f2g

X-ray diffraction
1.57Å resolution

Crystal structure of SARS-CoV-2 N-protein C-terminal domain (apo form)

Released:
DOI: 10.2210/pdb9f2g/pdb
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PDB entry 9f2g coloured by chain, front view.
PDB entry 9f2g coloured by chain, side view.
PDB entry 9f2g coloured by chain, top view.
Source organism: Severe acute respiratory syndrome coronavirus 2
Primary publication:
The ALS drug riluzole binds to the C-terminal domain of SARS-CoV-2 nucleocapsid protein and has antiviral activity.
Márquez-Moñino MÁ, Santiveri CM, de León P, Camero S, Campos-Olivas R, Jiménez MÁ, Sáiz M, González B, Pérez-Cañadillas JM
Structure (2024)
PMID: 39541975

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145015 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoprotein Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 111 amino acids
Theoretical weight: 12.53 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P0DTC9 (Residues: 256-364; Coverage: 26%)
Gene name: N

Ligands and Environments

2 bound ligands:
Ligand GOL 5 x GOL
Ligand SO4 5 x SO4
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: P21
Unit cell:
a: 92.704Å b: 45.14Å c: 109.061Å
α: 90° β: 93.96° γ: 90°
R-values:
R R work R free
0.191 0.189 0.229
Expression system: Escherichia coli BL21(DE3)

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