› 9f5j

X-ray diffraction
2.2Å resolution

SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant Q58I

Released:
DOI: 10.2210/pdb9f5j/pdb
PDB entry 9f5j coloured by chain, front view.
PDB entry 9f5j coloured by chain, side view.
PDB entry 9f5j coloured by chain, top view.
Source organism: Severe acute respiratory syndrome coronavirus 2
Primary publication:
A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding.
Dhamotharan K, Korn SM, Wacker A, Becker MA, Günther S, Schwalbe H, Schlundt A
Nat Commun 15 10656 (2024)
PMID: 39653699

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144998 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoprotein Chains: A, B
Molecule details ›
Chains: A, B
Length: 138 amino acids
Theoretical weight: 14.91 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P0DTC9 (Residues: 44-180; Coverage: 33%)
Gene name: N
Sequence domains: Coronavirus nucleocapsid

Ligands and Environments

1 bound ligand:
Ligand CD 4 x CD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)
Spacegroup: P212121
Unit cell:
a: 47.78Å b: 49.715Å c: 114.248Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.202 0.242
Expression system: Escherichia coli BL21(DE3)

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