› 9f7h

X-ray diffraction
1.43Å resolution

UP1 in complex with Z45617795

Released:
DOI: 10.2210/pdb9f7h/pdb
Model geometry
Fit model/data
PDB entry 9f7h coloured by chain, front view.
PDB entry 9f7h coloured by chain, side view.
PDB entry 9f7h coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Enhanced identification of small molecules binding to hnRNPA1 via cryptic pockets mapping coupled with X-Ray fragment screening.
Dunnett L, Das S, Venditti V, Prischi F
J Biol Chem 108335 (2025)
PMID: 39984046

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140720 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed Chain: A
Molecule details ›
Chain: A
Length: 198 amino acids
Theoretical weight: 22.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P09651 (Residues: 2-195; Coverage: 52%)
Gene names: HNRNPA1, HNRPA1
Sequence domains: RNA recognition motif

Ligands and Environments

1 bound ligand:
Ligand JFM 1 x JFM
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P21
Unit cell:
a: 37.957Å b: 43.907Å c: 56.19Å
α: 90° β: 94.38° γ: 90°
R-values:
R R work R free
0.18 0.179 0.2
Expression system: Escherichia coli BL21(DE3)

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