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Gcase in complex with small molecule inhibitor 1

Source organism: Homo sapiens
Biochemical function: glucosylceramidase activity
Biological process: sphingolipid metabolic process
Cellular component: not assigned

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EC 3.2.1.46: Galactosylceramidase

Reaction catalysed:
D-galactosyl-N-acylsphingosine + H(2)O = D-galactose + N-acylsphingosine
Systematic name:
D-galactosyl-N-acylsphingosine galactohydrolase
Alternative Name(s):
  • Beta-galactocerebrosidase
  • Beta-galactosylceramidase
  • Ceramide galactosidase
  • Cerebroside beta-galactosidase
  • Cerebroside galactosidase
  • Galactocerebrosidase
  • Galactocerebroside beta-galactosidase
  • Galactocerebroside galactosidase
  • Galactocerebroside-beta-D-galactosidase
  • Galactocerebroside.beta-galactosidase
  • Galactosylceramidase I
  • Galactosylceramide beta-galactosidase
  • Galactosylceramide.beta-galactosidase
  • Galactosylcerebrosidase
  • Galcerase
  • Lactosylceramidase
  • Lactosylceramidase I

EC 3.2.1.45: Glucosylceramidase

Reaction catalysed:
D-glucosyl-N-acylsphingosine + H(2)O = D-glucose + N-acylsphingosine
Systematic name:
D-glucosyl-N-acylsphingosine glucohydrolase
Alternative Name(s):
  • Acid beta-glucosidase
  • Beta-D-glucocerebrosidase
  • Beta-glucocerebrosidase
  • Beta-glucosylceramidase
  • Ceramide glucosidase
  • GlcCer-beta-glucosidase
  • Glucocerebrosidase
  • Glucosphingosine glucosylhydrolase
  • Glucosylcerebrosidase
  • Glucosylsphingosine beta-D-glucosidase
  • Glucosylsphingosine beta-glucosidase
  • Psychosine hydrolase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF17189
Domain description: Glycosyl hydrolase family 30 beta sandwich domain
Occurring in:
  1. Lysosomal acid glucosylceramidase

PF02055
Domain description: Glycosyl hydrolase family 30 TIM-barrel domain
Occurring in:
  1. Lysosomal acid glucosylceramidase

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