› 9frv

X-ray diffraction
2.06Å resolution

Arginase 2 in complex with inhibitor

Released:
DOI: 10.2210/pdb9frv/pdb
PDB entry 9frv coloured by chain, front view.
PDB entry 9frv coloured by chain, side view.
PDB entry 9frv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Design and Synthesis of Acyclic Boronic Acid Arginase Inhibitors.
Shields JD, Aquila BM, Emmons D, Finlay MRV, Gangl ET, Gu C, Mlynarski SN, Petersen J, Pop-Damkov P, Sha L, Simpson I, Tavakoli S, Tentarelli S, Wang H, Ye Q, Zheng X
J Med Chem (2024)
PMID: 39540340

Function and Biology Details

Reaction catalysed: 
L-arginine + H(2)O = L-ornithine + urea
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160277 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Arginase-2, mitochondrial Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 336 amino acids
Theoretical weight: 36.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P78540 (Residues: 22-341; Coverage: 90%)
Gene name: ARG2
Sequence domains: Arginase family

Ligands and Environments

2 bound ligands:
Ligand MN 6 x MN
Ligand A1IFX 1 x A1IFX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: P212121
Unit cell:
a: 46.749Å b: 134.59Å c: 145.081Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.28 0.279 0.315
Expression system: Escherichia coli

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