Function and Biology Details
Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero 25-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-283751 (preferred)
Entry contents:
23 distinct polypeptide molecules
2 distinct DNA molecules
2 distinct DNA molecules
Macromolecules (25 distinct):
DNA-directed RNA polymerase III subunit RPC1
Chain: A
Molecule details ›
Chain: A
Length: 1390 amino acids
Theoretical weight: 155.86 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 1390 amino acids
Theoretical weight: 155.86 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
O14802 (Residues: 1-1390; Coverage: 100%)
Sequence domains:
DNA-directed RNA polymerase III subunit RPC2
Chain: B
Molecule details ›
Chain: B
Length: 1133 amino acids
Theoretical weight: 127.95 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 1133 amino acids
Theoretical weight: 127.95 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q9NW08 (Residues: 1-1133; Coverage: 100%)
Sequence domains:
DNA-directed RNA polymerase III subunit RPC3
Chain: C
Molecule details ›
Chain: C
Length: 534 amino acids
Theoretical weight: 60.69 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 534 amino acids
Theoretical weight: 60.69 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q9BUI4 (Residues: 1-534; Coverage: 100%)
Sequence domains:
DNA-directed RNA polymerase III subunit RPC4
Chain: D
Molecule details ›
Chain: D
Length: 398 amino acids
Theoretical weight: 44.47 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: RNA polymerase III RPC4
Length: 398 amino acids
Theoretical weight: 44.47 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P05423 (Residues: 1-398; Coverage: 100%)
Sequence domains: RNA polymerase III RPC4
DNA-directed RNA polymerase III subunit RPC5
Chain: E
Molecule details ›
Chain: E
Length: 708 amino acids
Theoretical weight: 80 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 708 amino acids
Theoretical weight: 80 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q9NVU0 (Residues: 1-708; Coverage: 100%)
Sequence domains:
DNA-directed RNA polymerase III subunit RPC6
Chain: F
Molecule details ›
Chain: F
Length: 316 amino acids
Theoretical weight: 35.73 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: RNA polymerase Rpc34 subunit
Length: 316 amino acids
Theoretical weight: 35.73 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q9H1D9 (Residues: 1-316; Coverage: 100%)
Sequence domains: RNA polymerase Rpc34 subunit
DNA-directed RNA polymerase III subunit RPC7
Chain: G
Molecule details ›
Chain: G
Length: 223 amino acids
Theoretical weight: 25.95 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: DNA-directed RNA polymerase III subunit Rpc31
Length: 223 amino acids
Theoretical weight: 25.95 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
O15318 (Residues: 1-223; Coverage: 100%)
Sequence domains: DNA-directed RNA polymerase III subunit Rpc31
DNA-directed RNA polymerase III subunit RPC8
Chain: H
Molecule details ›
Chain: H
Length: 204 amino acids
Theoretical weight: 22.94 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 204 amino acids
Theoretical weight: 22.94 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q9Y535 (Residues: 1-204; Coverage: 100%)
Sequence domains:
DNA-directed RNA polymerase III subunit RPC9
Chain: I
Molecule details ›
Chain: I
Length: 148 amino acids
Theoretical weight: 16.89 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: RNA polymerase Rpb4
Length: 148 amino acids
Theoretical weight: 16.89 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
O75575 (Residues: 1-148; Coverage: 100%)
Sequence domains: RNA polymerase Rpb4
DNA-directed RNA polymerase III subunit RPC10
Chain: J
Molecule details ›
Chain: J
Length: 108 amino acids
Theoretical weight: 12.35 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 108 amino acids
Theoretical weight: 12.35 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q9Y2Y1 (Residues: 1-108; Coverage: 100%)
Sequence domains:
DNA-directed RNA polymerases I and III subunit RPAC1
Chain: K
Molecule details ›
Chain: K
Length: 346 amino acids
Theoretical weight: 39.3 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 346 amino acids
Theoretical weight: 39.3 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
O15160 (Residues: 1-346; Coverage: 100%)
Sequence domains:
DNA-directed RNA polymerases I and III subunit RPAC2
Chain: L
Molecule details ›
Chain: L
Length: 133 amino acids
Theoretical weight: 15.26 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: RNA polymerase Rpb3/Rpb11 dimerisation domain
Length: 133 amino acids
Theoretical weight: 15.26 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P0DPB6 (Residues: 1-133; Coverage: 100%)
Sequence domains: RNA polymerase Rpb3/Rpb11 dimerisation domain
DNA-directed RNA polymerases I, II, and III subunit RPABC1
Chain: M
Molecule details ›
Chain: M
Length: 210 amino acids
Theoretical weight: 24.58 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 210 amino acids
Theoretical weight: 24.58 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P19388 (Residues: 1-210; Coverage: 100%)
Sequence domains:
DNA-directed RNA polymerases I, II, and III subunit RPABC2
Chain: N
Molecule details ›
Chain: N
Length: 127 amino acids
Theoretical weight: 14.49 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: RNA polymerase Rpb6
Length: 127 amino acids
Theoretical weight: 14.49 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P61218 (Residues: 1-127; Coverage: 100%)
Sequence domains: RNA polymerase Rpb6
DNA-directed RNA polymerases I, II, and III subunit RPABC3
Chain: O
Molecule details ›
Chain: O
Length: 150 amino acids
Theoretical weight: 17.16 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: RNA polymerase Rpb8
Length: 150 amino acids
Theoretical weight: 17.16 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P52434 (Residues: 1-150; Coverage: 100%)
Sequence domains: RNA polymerase Rpb8
DNA-directed RNA polymerases I, II, and III subunit RPABC4
Chain: P
Molecule details ›
Chain: P
Length: 58 amino acids
Theoretical weight: 7.02 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: DNA directed RNA polymerase, 7 kDa subunit
Length: 58 amino acids
Theoretical weight: 7.02 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P53803 (Residues: 1-58; Coverage: 100%)
Sequence domains: DNA directed RNA polymerase, 7 kDa subunit
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Chain: Q
Molecule details ›
Chain: Q
Length: 67 amino acids
Theoretical weight: 7.66 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: RNA polymerases N / 8 kDa subunit
Length: 67 amino acids
Theoretical weight: 7.66 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P62875 (Residues: 1-67; Coverage: 100%)
Sequence domains: RNA polymerases N / 8 kDa subunit
TATA-box-binding protein
Chain: R
Molecule details ›
Chain: R
Length: 200 amino acids
Theoretical weight: 22.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Transcription factor TFIID (or TATA-binding protein, TBP)
Length: 200 amino acids
Theoretical weight: 22.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P20226 (Residues: 159-339; Coverage: 53%)
Sequence domains: Transcription factor TFIID (or TATA-binding protein, TBP)
Transcription factor IIIB 50 kDa subunit
Chain: S
Molecule details ›
Chain: S
Length: 419 amino acids
Theoretical weight: 46.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 419 amino acids
Theoretical weight: 46.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q9HAW0 (Residues: 1-419; Coverage: 100%)
Sequence domains:
Transcription factor TFIIIB component B'' homolog
Chain: T
Molecule details ›
Chain: T
Length: 484 amino acids
Theoretical weight: 55.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Myb DNA-binding like
Length: 484 amino acids
Theoretical weight: 55.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
A6H8Y1 (Residues: 1-484; Coverage: 18%)
Sequence domains: Myb DNA-binding like
snRNA-activating protein complex subunit 1
Chain: U
Molecule details ›
Chain: U
Length: 368 amino acids
Theoretical weight: 43.07 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Small nuclear RNA activating complex (SNAPc), subunit 1
Length: 368 amino acids
Theoretical weight: 43.07 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q16533 (Residues: 1-368; Coverage: 100%)
Sequence domains: Small nuclear RNA activating complex (SNAPc), subunit 1
snRNA-activating protein complex subunit 4
Chain: W
Molecule details ›
Chain: W
Length: 1519 amino acids
Theoretical weight: 165.12 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Myb-like DNA-binding domain
Length: 1519 amino acids
Theoretical weight: 165.12 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q5SXM2 (Residues: 2-1469; Coverage: 100%)
Sequence domains: Myb-like DNA-binding domain
snRNA-activating protein complex subunit 3
Chain: Z
Molecule details ›
Chain: Z
Length: 411 amino acids
Theoretical weight: 46.81 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: snRNA-activating protein complex (SNAPc), subunit 3
Length: 411 amino acids
Theoretical weight: 46.81 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q92966 (Residues: 1-411; Coverage: 100%)
Sequence domains: snRNA-activating protein complex (SNAPc), subunit 3
U6_2_Template
Chain: X
Molecule details ›
Chain: X
Length: 98 nucleotides
Theoretical weight: 30.18 KDa
Length: 98 nucleotides
Theoretical weight: 30.18 KDa
U6_2_Non template
Chain: Y
Molecule details ›
Chain: Y
Length: 98 nucleotides
Theoretical weight: 30.28 KDa
Length: 98 nucleotides
Theoretical weight: 30.28 KDa