9fsq

Electron Microscopy
3.51Å resolution

RNA Polymerase III Class III Melting Pre-Initiation Complex (MC)

Released:

Function and Biology Details

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero 25-mer (preferred)
PDBe Complex ID:
PDB-CPX-283751 (preferred)
Entry contents:
23 distinct polypeptide molecules
2 distinct DNA molecules
Macromolecules (25 distinct):
DNA-directed RNA polymerase III subunit RPC1 Chain: A
Molecule details ›
Chain: A
Length: 1390 amino acids
Theoretical weight: 155.86 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O14802 (Residues: 1-1390; Coverage: 100%)
Gene name: POLR3A
Sequence domains:
DNA-directed RNA polymerase III subunit RPC2 Chain: B
Molecule details ›
Chain: B
Length: 1133 amino acids
Theoretical weight: 127.95 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NW08 (Residues: 1-1133; Coverage: 100%)
Gene name: POLR3B
Sequence domains:
DNA-directed RNA polymerase III subunit RPC3 Chain: C
DNA-directed RNA polymerase III subunit RPC4 Chain: D
DNA-directed RNA polymerase III subunit RPC5 Chain: E
DNA-directed RNA polymerase III subunit RPC6 Chain: F
DNA-directed RNA polymerase III subunit RPC7 Chain: G
DNA-directed RNA polymerase III subunit RPC8 Chain: H
DNA-directed RNA polymerase III subunit RPC9 Chain: I
DNA-directed RNA polymerase III subunit RPC10 Chain: J
DNA-directed RNA polymerases I and III subunit RPAC1 Chain: K
DNA-directed RNA polymerases I and III subunit RPAC2 Chain: L
DNA-directed RNA polymerases I, II, and III subunit RPABC1 Chain: M
DNA-directed RNA polymerases I, II, and III subunit RPABC2 Chain: N
DNA-directed RNA polymerases I, II, and III subunit RPABC3 Chain: O
DNA-directed RNA polymerases I, II, and III subunit RPABC4 Chain: P
DNA-directed RNA polymerases I, II, and III subunit RPABC5 Chain: Q
TATA-box-binding protein Chain: R
Transcription factor IIIB 50 kDa subunit Chain: S
Transcription factor TFIIIB component B'' homolog Chain: T
snRNA-activating protein complex subunit 1 Chain: U
snRNA-activating protein complex subunit 4 Chain: W
snRNA-activating protein complex subunit 3 Chain: Z
U6_2_Template Chain: X
U6_2_Non template Chain: Y

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.51Å
Relevant EMDB volumes: EMD-50732
Expression systems:
  • Escherichia coli
  • Trichoplusia ni