› 9g4s

X-ray diffraction
1.95Å resolution

Crystal structure of the human METTL3-METTL14 in complex with small molecule inhibitor Compound 56

Released:
DOI: 10.2210/pdb9g4s/pdb
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PDB entry 9g4s coloured by chain, front view.
PDB entry 9g4s coloured by chain, side view.
PDB entry 9g4s coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dutheuil G, Oukoloff K

Function and Biology Details

Reaction catalysed: 
S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N(6)-methyladenine in mRNA
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183176 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
N(6)-adenosine-methyltransferase catalytic subunit METTL3 Chain: A
Molecule details ›
Chain: A
Length: 214 amino acids
Theoretical weight: 24.66 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q86U44 (Residues: 365-578; Coverage: 37%)
Gene names: METTL3, MTA70
Sequence domains: MT-A70
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14 Chain: B
Molecule details ›
Chain: B
Length: 280 amino acids
Theoretical weight: 32.53 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9HCE5 (Residues: 116-395; Coverage: 61%)
Gene names: KIAA1627, METTL14
Sequence domains: MT-A70

Ligands and Environments

3 bound ligands:
Ligand A1III 1 x A1III
Ligand CA 5 x CA
Ligand TRS 1 x TRS
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P3221
Unit cell:
a: 64.191Å b: 64.191Å c: 225.132Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.198 0.195 0.243
Expression system: Spodoptera frugiperda

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