› 9g8r

Electron Microscopy
3.4Å resolution

human SKI7-SKI238 complex in the open state

Released:
DOI: 10.2210/pdb9g8r/pdb
PDB entry 9g8r coloured by chain, front view.
PDB entry 9g8r coloured by chain, side view.
PDB entry 9g8r coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of mRNA decay by the human exosome-ribosome supercomplex.
Kögel A, Keidel A, Loukeri MJ, Kuhn CC, Langer LM, Schäfer IB, Conti E
Nature (2024)
PMID: 39385025
Related structures: EMD-51137

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-278775 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Superkiller complex protein 3 Chain: B
Molecule details ›
Chain: B
Length: 1568 amino acids
Theoretical weight: 176.06 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
WD repeat-containing protein 61 Chains: C, D
Molecule details ›
Chains: C, D
Length: 305 amino acids
Theoretical weight: 33.62 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Isoform 2 of HBS1-like protein Chain: E
Molecule details ›
Chain: E
Length: 179 amino acids
Theoretical weight: 19.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Superkiller complex protein 2 Chain: A
Molecule details ›
Chain: A
Length: 976 amino acids
Theoretical weight: 107.62 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-51137
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli

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