› 9gdl

Solution NMR

Trp-cage fortified Tc5b-Exenatide chimera with disulfide bond cyclization (Ex-4-Tc5bCC) at 277K

Released:
DOI: 10.2210/pdb9gdl/pdb
PDB entry 9gdl coloured by chain, ensemble of 10 models, front view.
PDB entry 9gdl coloured by chain, ensemble of 10 models, side view.
PDB entry 9gdl coloured by chain, ensemble of 10 models, top view.
Source organism: Heloderma suspectum
Primary publication:
Influence of Trp-Cage on the Function and Stability of GLP-1R Agonist Exenatide Derivatives.
Horváth D, Stráner P, Taricska N, Fazekas Z, Menyhárd DK, Perczel A
J Med Chem (2024)
PMID: 39254428

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-251790 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Trp-cage fortified Tc5b-Exenatide chimera (Ex-4-Tc5bSS) Chain: A
Molecule details ›
Chain: A
Length: 25 amino acids
Theoretical weight: 2.82 KDa
Source organism: Heloderma suspectum
Expression system: Escherichia coli

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 52%
Refinement method: simulated annealing
Expression system: Escherichia coli

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