› 9h7f

X-ray diffraction
1.24Å resolution

Human Transthyretin in Complex with 3,5-dichloroaniline

Released:
DOI: 10.2210/pdb9h7f/pdb
Model geometry
Fit model/data
PDB entry 9h7f coloured by chain, front view.
PDB entry 9h7f coloured by chain, side view.
PDB entry 9h7f coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Fragment-Based Drug Discovery for Transthyretin Kinetic Stabilisers Using a Novel Capillary Zone Electrophoresis Method
Chen W
Biorxiv (2025)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 13.78 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family

Ligands and Environments

1 bound ligand:
Ligand A1ISU 1 x A1ISU
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P21212
Unit cell:
a: 85.11Å b: 43.8Å c: 64.76Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.157 0.155 0.178
Expression system: Homo sapiens

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